Some trans people are able to avoid the medical community's requirements for hormone therapy altogether by either obtaining hormones from black market sources, such as internet pharmacies which ship from overseas, or more rarely, by synthesizing hormones themselves. Notably, the Roman Catholic church, according to an unpublished Vatican document, holds that changing sex is not possible and, while in some cases treatment might be necessary, it does not change the person's sex in the eyes of the church. Cross-sex hormones are usually recommended at the age of sixteen 7. In adolescents, careful diagnosis and following strict criteria can ensure good post-operative outcomes. But in trans men, some hormonally-induced changes may become virtually irreversible within weeks, whereas trans women usually have to take hormones for many months before any irreversible changes will result. Participation in support groups, available in most large cities, is usually helpful. In addition, testosterone appeared to counteract endometrial proliferation induced by estrogen to a certain extent In our center, a three-member team comprising two Endocrinologists and one Psychiatrist is involved in the process of confirming the diagnosis based on the DSM SRS may encompass any surgical procedures which will reshape a male body into a body with a female appearance or vice versa, or more specifically refer to the procedures used to make male genitals into female genitals and vice versa. It is always advised that all changes in therapeutic hormonal treatment should be supervised by a physician because starting, stopping or even changing dosage rates and levels can have physical and psychological health risks. Therefore, many surgeons are willing to perform some or all elements of sex reassignment surgery without a real-life test. Design Description of cases of transsexuals who have developed a hormone-related malignancy observed in their own clinic or reported in the literature. The descriptive statistical analysis is carried out in the present study. Standards of care documents provide clinical guidance for health professionals about the optimal management of transsexual people. The DSM-IV itself states that in rare instances, gender dysphoria may co-exist with schizophrenia, and that psychiatric disorders are generally not considered contraindications to sex reassignment therapy unless they are the primary cause of the patient's gender dysphoria. After reassignment surgery, which includes gonadectomy, hormone therapy must be continued. Our objective is to study the therapeutic options including psychotherapy, hormone, and surgical treatments used for alleviating GD in male—to—female MTF transgender subjects in Eastern India.